Discrimination of Normal Gastric Mucosa from Helicobacter pylori Gastritis using Standard Endoscopes and a Single Observation Site: Studies in Children and Young Adults
- 2 April 2004
- journal article
- Published by Wiley in Helicobacter
- Vol. 9 (2), 95-99
- https://doi.org/10.1111/j.1083-4389.2004.00204.x
Abstract
Background. In the Helicobacter pylori-negative normal stomach, collecting venules are visible in the gastric corpus as numerous minute points. This finding has been termed ‘regular arrangement of collecting venules’ (RAC). The aim of the present study was to investigate the reliability of the presence of the RAC pattern for discrimination of normal gastric mucosa from H. pylori gastritis in pediatric patients. Methods. Fifty-two consecutive children, adolescents and young adults (male:female 24 : 28; median age 15 years, range 8–29 years) referred for endoscopy and assessed for H. pylori infection were prospectively studied. The lower lesser curvature of the corpus near the incisura was evaluated for the RAC pattern using a standard endoscope with the tip close to, but not in contact with, the gastric surface. Gastric biopsies were taken after the endoscopic observation. Results. In all the 29 RAC-positive patients, active H. pylori gastritis was absent, whereas H. pylori gastritis was found in 20 of 23 RAC-negative patients (86.9%). Conclusions. Identification of the RAC pattern at the lower lesser curvature of the corpus using close observation with a standard endoscope proved to be an effective and practical marker to discriminate normal histology from H. pylori gastritis among both children and young adults. Absence of the RAC pattern should prompt gastric mucosal biopsies despite otherwise normal-appearing gastric mucosa.Keywords
This publication has 13 references indexed in Scilit:
- Relationship between histopathologic gastritis and mucosal microvascularity: Observations with magnifying endoscopyGastrointestinal Endoscopy, 2003
- Diagnostic Accuracy of The 13C-Urea Breath Test for Childhood Helicobacter Pylori Infection: A Multicenter Japanese StudyAmerican Journal Of Gastroenterology, 2002
- Getting to Grips With Gastric PathologyJournal of Pediatric Gastroenterology and Nutrition, 2002
- Correlation of Endoscopy and Histology in the Gastroesophageal Mucosa in ChildrenJournal of Clinical Gastroenterology, 2000
- Interobserver agreement and predictive value of endoscopic findings for H. pylori and gastritis in normal volunteersGastrointestinal Endoscopy, 1995
- Helicobacter pylori, gastroduodenal disease, and recurrent abdominal pain in childrenPublished by American Medical Association (AMA) ,1995
- Gastroscopy is incomplete without biopsy: Clinical relevance of distinguishing gastropathy from gastritisGastroenterology, 1995
- Comparison of biopsy sites for the histopathologic diagnosis of Helicobacter pylori: a topographic study of H. pylori density and distributionGastrointestinal Endoscopy, 1994
- Unique features ofHelicobacter pylori disease in childrenDigestive Diseases and Sciences, 1991
- Association ofCampylobacter pylorion the Gastric Mucosa with Antral Gastritis in ChildrenNew England Journal of Medicine, 1987