Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1
- 14 October 1994
- journal article
- Published by Elsevier BV in European Journal of Pharmacology: Molecular Pharmacology
- Vol. 269 (2), 219-224
- https://doi.org/10.1016/0922-4106(94)90089-2
Abstract
No abstract availableKeywords
This publication has 14 references indexed in Scilit:
- The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (Tiagabine) as an anticonvulsant drug candidateJournal of Medicinal Chemistry, 1993
- Functional expression and CNS distribution of a β-alanine-sensitive neuronal GABA transporterNeuron, 1992
- Cloning and expression of a glycine transporter reveal colocalization with NMDA receptorsNeuron, 1992
- Anticonvulsant Profiles of the Potent and Orally Active GABA Uptake Inhibitors SK&F 89976-A and SK&F 100330-A and Four Prototype Antiepileptic Drugs in Mice and RatsEpilepsia, 1991
- Cloning and Expression of a Rat Brain GABA TransporterScience, 1990
- Pharmacology of Cl‐966: A potent GABA uptake inhibitor, in vitro and in experimental animalsDrug Development Research, 1990
- Synthesis and metabolic profile of Cl‐966: A potent, orally‐active inhibitor of GABA uptakeDrug Development Research, 1990
- Initial human safety and tolerance study of a GABA uptake inhibitor, Cl‐966: Potential role of GABA as a mediator in the pathogenesis of schizophrenia and maniaDrug Development Research, 1990
- GABA uptake inhibitors: relevance to antiepileptic drug researchEpilepsy Research, 1987
- Orally Active and Potent Inhibitors of γ-Aminobutyric Acid UptakeJournal of Medicinal Chemistry, 1985