Rectal Cancer in Common Variable Immunodeficiency: A Case Report

Abstract

Journal of clinical gastroenterology is part of the Juniper publishers which is devoted to publish subject-specific articles focused on the needs of individual research communities across all areas of biology and medicine. Common variable immunodeficiency (CVID) is a primary immunodeficiency related predominantly to immunoglobulin (Ig) G and IgA deficiency with or without changes in IgM levels. Other immunological pathways may also be altered, which makes this pathology extremely heterogeneous. The main manifestations include predisposition to severe infections, development of autoimmune diseases and greater susceptibility to the development of neoplasms, especially lymphomas and gastric cancer. There are reports of colorectal and anal cancer in this population, very variable in terms of histology (lymphomas, squamous cell carcinoma), but little is found about rectal adenocarcinoma concomitantly with CVID and ulcerative colitis (UC). The objective of this case report is to demonstrate the unusual association between colorectal cancer in a young patient presenting CVID.