Association of GUCY2C Expression in Lymph Nodes With Time to Recurrence and Disease-Free Survival in pN0 Colorectal Cancer
Open Access
- 18 February 2009
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 301 (7), 745-752
- https://doi.org/10.1001/jama.2009.141
Abstract
Metastasis of tumor cells to regional lymph nodes is the single most important prognostic factor in patients with colorectal cancer.1,2 Recurrence rates increase from approximately 25% in patients with lymph nodes free of tumor cells by histopathology (pN0) to approximately 50% in patients with 4 or more lymph nodes harboring metastases.3,4 Adjuvant chemotherapy improves disease-free and overall survival in patients with histopathologically evident lymph node metastases, but its role in patients with pN0 colorectal cancer remains unclear.5-9Keywords
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