Carbon Nanotubes Activate Blood Platelets by Inducing Extracellular Ca2+ Influx Sensitive to Calcium Entry Inhibitors
- 28 July 2009
- journal article
- letter
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 9 (9), 3312-3317
- https://doi.org/10.1021/nl901603k
Abstract
To elucidate a mechanism of prothrombotic effects of carbon nanotubes (CNTs), we report here that multiwalled CNTs activate blood platelets by inducing extracellular Ca(2+) influx that could be inhibited by calcium channel blockers SKF 96365 and 2-APB. We also demonstrate platelet aggregating activity of different single-walled and multiwalled CNTs. In addition, we show that CNT-induced platelet activation is associated with a marked release of platelet membrane microparticles positive for the granular secretion markers CD62P and CD63.Keywords
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