Predictive factors for osteoradionecrosis of the jaws: A retrospective study
- 17 November 2017
- journal article
- research article
- Published by Wiley in Head & Neck
- Vol. 40 (1), 46-54
- https://doi.org/10.1002/hed.24907
Abstract
Osteoradionecrosis of the jaw (ORNJ) is a well-recognized complication of radiotherapy. The purpose of this study was to assess predictive factors for the development of ORNJ. A retrospective study of 325 patients with head and neck squamous cell carcinoma (HNSCC) treated at one institution between January 1, 1999, and December 31, 2008, was conducted. Outcome measure was the presence/absence of ORNJ. Time to event was recorded and Cox proportional hazard regression analysis was used to determine statistically significant predictive factors. Fifty-nine patients had ORNJ. Statistical analysis using Cox regression analysis identified several statistically significant variables: dentoalveolar surgery; peri-resective surgery of the jaw; continued tobacco usage after radiotherapy, diabetes mellitus type 2 (DM2); and total radiation dose. Patients at greater risk of developing ORNJ can be identified and measures can be instituted to reduce its incidence and expedite management when it does occur.Keywords
This publication has 44 references indexed in Scilit:
- Radiotherapy for the management of locally advanced squamous cell carcinoma of the head and neckOral Diseases, 2009
- Oral complications of radiotherapyThe Lancet Oncology, 2006
- Effects of radiation on normal tissue: consequences and mechanismsThe Lancet Oncology, 2003
- Mandibular osteoradionecrosis: clinical behaviour and diagnostic aspectsClinical Otolaryngology, 2000
- Conservative management of osteoradionecrosisOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 1997
- The conservative management of osteoradionecrosis of the mandible with ultrasound therapyBritish Journal of Oral and Maxillofacial Surgery, 1992
- Studies in the radiobiology of osteoradionecrosis and their clinical significanceOral Surgery, Oral Medicine, Oral Pathology, 1987
- Osteoradionecrosis: Clinical experience and a proposal for classificationJournal of Oral and Maxillofacial Surgery, 1987
- Osteoradionecrosis: Predisposing factors and outcomes of therapyHead & Neck Surgery, 1984
- Osteoradionecrosis: A new concept of its pathophysiologyJournal of Oral and Maxillofacial Surgery, 1983