Mitochondrial Uncoupling: A Key Contributor to Reduced Cardiac Efficiency in Diabetes
- 1 August 2006
- journal article
- review article
- Published by American Physiological Society in Physiology
- Vol. 21 (4), 250-258
- https://doi.org/10.1152/physiol.00008.2006
Abstract
Cardiovascular disease is the primary cause of death in individuals with obesity and diabetes. However, the underlying mechanisms for cardiac dysfunction are partially understood. Studies have suggested that altered cardiac metabolism may play a role. The diabetic heart is characterized by increased fatty acid oxidation, increased myocardial oxygen consumption, and reduced cardiac efficiency. Here, we review possible mechanisms for reduced cardiac efficiency in obesity and diabetes by focusing on the potential role of mitochondrial uncoupling.Keywords
This publication has 109 references indexed in Scilit:
- Uncoupling Proteins 2 and 3 Function in Concert to Augment Tolerance to Cardiac IschemiaOnline Journal of Public Health Informatics, 2005
- Mechanisms of Lipoapoptosis: Implications for Human Heart DiseaseTrends in Cardiovascular Medicine, 2002
- Superoxide activates mitochondrial uncoupling proteinsNature, 2002
- Global and societal implications of the diabetes epidemicNature, 2001
- Myocardial substrate metabolism: Implications for diabetic CardiomyopathyJournal of Molecular and Cellular Cardiology, 1995
- Regulation of fatty acid oxidation in the mammalian heart in health and diseaseBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1994
- Glucose oxidation rates in fatty acid-perfused isolated working hearts from diabetic ratsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1989
- Mitochondrial creatine phosphokinase deficiency in diabetic rat heartBiochemical and Biophysical Research Communications, 1988
- Effect of increased free fatty acids on myocardial oxygen extraction and angina threshold during atrial pacing.Circulation, 1977
- New type of cardiomyopathy associated with diabetic glomerulosclerosisThe American Journal of Cardiology, 1972