Electrocorticographic control of a prosthetic arm in paralyzed patients
- 2 November 2011
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 71 (3), 353-361
- https://doi.org/10.1002/ana.22613
Abstract
Objective: Paralyzed patients may benefit from restoration of movement afforded by prosthetics controlled by electrocorticography (ECoG). Although ECoG shows promising results in human volunteers, it is unclear whether ECoG signals recorded from chronically paralyzed patients provide sufficient motor information, and if they do, whether they can be applied to control a prosthetic. Methods: We recorded ECoG signals from sensorimotor cortices of 12 patients while they executed or attempted to execute 3 to 5 simple hand and elbow movements. Sensorimotor function was severely impaired in 3 patients due to peripheral nervous system lesion or amputation, moderately impaired due to central nervous system lesions sparing the cortex in 4 patients, and normal in 5 patients. Time frequency and decoding analyses were performed with the patients' ECoG signals. Results: In all patients, the high gamma power (80–150Hz) of the ECoG signals during movements was clearly responsive to movement types and provided the best information for classifying different movement types. The classification performance was significantly better than chance in all patients, although differences between ECoG power modulations during different movement types were significantly less in patients with severely impaired motor function. In the impaired patients, cortical representations tended to overlap each other. Finally, using the classification method in real time, a moderately impaired patient and 3 nonparalyzed patients successfully controlled a prosthetic arm. Interpretation: ECoG signals appear useful for prosthetic arm control and may provide clinically feasible motor restoration for patients with paralysis but no injury of the sensorimotor cortex. ANN NEUROL 2012;Keywords
This publication has 28 references indexed in Scilit:
- Decoupling the Cortical Power Spectrum Reveals Real-Time Representation of Individual Finger Movements in HumansJournal of Neuroscience, 2009
- Two-dimensional movement control using electrocorticographic signals in humansJournal of Neural Engineering, 2008
- Prediction of arm movement trajectories from ECoG-recordings in humansJournal of Neuroscience Methods, 2008
- Decoding two-dimensional movement trajectories using electrocorticographic signals in humansJournal of Neural Engineering, 2007
- The Emerging World Of Motor Neuroprosthetics: a Neurosurgical PerspectiveNeurosurgery, 2006
- Brain Reorganization After StrokeTopics in Stroke Rehabilitation, 2003
- Adaptation in the motor cortex following cervical spinal cord injuryNeurology, 2002
- How does the human brain deal with a spinal cord injury?European Journal of Neuroscience, 1998
- Neural Substrates for the Effects of Rehabilitative Training on Motor Recovery After Ischemic InfarctScience, 1996
- Perceptual Correlates of Massive Cortical ReorganizationScience, 1992