CXCR5+ CCR7– CD8 T cells are early effector memory cells that infiltrate tonsil B cell follicles
Open Access
- 29 November 2007
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 37 (12), 3352-3362
- https://doi.org/10.1002/eji.200636746
Abstract
Naive and central memory CD8 T cells use CCR7 to recirculate through T cell zones of secondary lymphoid organs where they can encounter antigen. Here we describe a subset of human CD8 T cells expressing CXCR5 which enables homing in response to CXCL13 produced within B cell follicles. CXCR5+ CD8 T cells were found in tonsil B cell follicles, and isolated cells migrated towards CXCL13 in vitro. They expressed CD27, CD28, CD45RO, CD69, and were CD7low, and produced IFN‐γ and granzyme A but lacked perforin, a functional profile suggesting that these cells are early effector memory cells in the context of contemporary T cell differentiation models. Receptors important in the interaction with B cells, including CD70, OX40 and ICOS, were induced upon activation, and CXCR5+ CD8 T cells could to some extent support survival and IgG production in tonsil B cells. Furthermore, CXCR5+ CD8 T cells expressed CCR5 but no CCR7, suggesting a migration pattern distinct from that of follicular CD4 T cells. The finding that a subset of early effector memory CD8 T cells use CXCR5 to locate to B cell follicles indicates that MHC class I‐restricted CD8 T cells are part of the follicular T cell population.Keywords
This publication has 48 references indexed in Scilit:
- Differential expression of human granzymes A, B, and K in natural killer cells and during CD8+ T cell differentiation in peripheral bloodEuropean Journal of Immunology, 2005
- ANTIGEN-SPECIFIC MEMORY B CELL DEVELOPMENTAnnual Review of Immunology, 2005
- UNDERSTANDING PRESENTATION OF VIRAL ANTIGENS TO CD8+T CELLS IN VIVO: The Key to Rational Vaccine DesignAnnual Review of Immunology, 2005
- CHEMOKINES, SPHINGOSINE-1-PHOSPHATE, AND CELL MIGRATION IN SECONDARY LYMPHOID ORGANSAnnual Review of Immunology, 2005
- Role of T cell costimulation in anti-viral immunitySeminars in Immunology, 2004
- Tumor Rejection Induced by CD70-mediated Quantitative and Qualitative Effects on Effector CD8+ T Cell FormationThe Journal of Experimental Medicine, 2004
- Memory CD8 T-Cell Differentiation during Viral InfectionJournal of Virology, 2004
- CD8+ T Cell Effector Mechanisms in Resistance to InfectionAnnual Review of Immunology, 2000
- Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsNature, 1999
- Phenotypic and Functional Separation of Memory and Effector Human CD8+ T CellsThe Journal of Experimental Medicine, 1997