The rapid and decremental change in haem oxygenase mRNA during erythroid differentiation of murine erythroleukaemia cells
- 1 December 1989
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 73 (4), 557-560
- https://doi.org/10.1111/j.1365-2141.1989.tb00297.x
Abstract
Changes in mRNA for haem oxygenase (HO), the rate-limiting enzyme for haem catabolism, were examined in murine Friend-virus transformed erythroleukaemia (MEL) cells while they were induced to undergo erythroid cell differentiation by treatment with dimethyl sulfoxide (DMSO). When MEL cells were treated with 1.5% (v/v) DMSO, a rapid decrease in HO mRNA content was observed (< 12 h) which reached the lowest value at 18 h (18% of the untreated control). HO mRNA levels remained at substantially lower levels (< 50%) than those in untreated controls thereafter. A rapid decline in HO mRNA may be involved in the cellular events that determine the onset of erythroid differentiation.This publication has 17 references indexed in Scilit:
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