The Role of Cerebrospinal Fluid Hypocretin Measurement in the Diagnosis of Narcolepsy and Other Hypersomnias
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Open Access
- 1 October 2002
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 59 (10), 1553-1562
- https://doi.org/10.1001/archneur.59.10.1553
Abstract
NARCOLEPSY IS characterized by sleepiness and abnormal rapid eye movement (REM) sleep events such as cataplexy, hypnagogic hallucinations, and sleep paralysis.1-3 Prevalence is in 0.02% to 0.05% of the population,4,5 with onset generally occuring in adolescence.1-3 Quality of life is as impaired as in epilepsy or depression.6 Most cases are sporadic, but twin and family studies demonstrate the existence of genetic factors.1,5 Current treatment involves psychostimulants for sleepiness and antidepressants for cataplexy.2,7 γ-Hydroxybutyrate is used to consolidate nocturnal sleep and reduce cataplexy.2,7,8Keywords
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