Neuroprotective Effects of the Green Tea Components Theanine and Catechins
Open Access
- 1 January 2002
- journal article
- review article
- Published by Pharmaceutical Society of Japan in Biological & Pharmaceutical Bulletin
- Vol. 25 (12), 1513-1518
- https://doi.org/10.1248/bpb.25.1513
Abstract
The neuroprotective effects of theanine and catechins contained in green tea are discussed. Although the death of cultured rat cortical neurons was induced by the application of glutamic acid, this neuronal death was suppressed with exposure to theanine. The death of hippocampal CA1 pyramidal neurons caused by transient forebrain ischemia in the gerbil was inhibited with the ventricular preadministration of theanine. The neuronal death of the hippocampal CA3 region by kainate was also prevented by the administration of theanine. Theanine has a higher binding capacity for the AMPA/kainate receptors than for NMDA receptors, although the binding capacity in all cases is markedly less than that of glutamic acid. The results of the present study suggest that the mechanism of the neuroprotective effect of theanine is related not only to the glutamate receptor but also to other mechanisms such as the glutamate transporter, although further studies are needed. One of the onset mechanisms for arteriosclerosis, a major factor in ischemic cerebrovascular disease, is probably the oxidative alteration of low-density lipoprotein (LDL) by active oxygen species. The oxidative alterations of LDL were shown to be prevented by tea catechins. Scavenging of ·O2− was also exhibited by tea catechins. The neuroprotective effects of theanine and catechins contained in green tea are a focus of considerable attention, and further studies are warranted.Keywords
This publication has 54 references indexed in Scilit:
- Protective effect of γ-glutamylethylamide (theanine) on ischemic delayed neuronal death in gerbilsNeuroscience Letters, 2000
- Effects of L-Theanine on the Release of .ALPHA.-Brain Waves in Human Volunteers.Journal of the agricultural chemical society of Japan, 1998
- NMDA Antagonist Neurotoxicity: Mechanism and PreventionScience, 1991
- Book ReviewAmbulatory Pediatric CareThe New England Journal of Medicine, 1989
- Anatomical organization of excitatory amino acid receptors and their pathwaysTrends in Neurosciences, 1987
- Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral MicrodialysisJournal of Neurochemistry, 1984
- Delayed neuronal death in the gerbil hippocampus following ischemiaBrain Research, 1982
- Temporal profile of neuronal damage in a model of transient forebrain ischemiaAnnals of Neurology, 1982
- Influence of Alkylamides of Glutamic Acid and Related Compounds on the Central Nervous System. I. Central Depressant Effect of TheanineCHEMICAL & PHARMACEUTICAL BULLETIN, 1971
- Studies on the Chemical Constituents of TeaJournal of the agricultural chemical society of Japan, 1950