Tablets of Functionalized Polystyrene Beads Alone and in Combination with Solid Reagents or Catalysts. Preparation and Applications in Parallel Solution and Solid Phase Synthesis
- 16 October 2003
- journal article
- Published by American Chemical Society (ACS) in Journal of Combinatorial Chemistry
- Vol. 5 (6), 842-850
- https://doi.org/10.1021/cc034019k
Abstract
Pretreatment of polystyrene beads with a nonpolar organic solvent is the key for the generation of mechanically robust tablets consisting of neat functionalized polystyrene beads, both alone and in combination with solid reagents or catalysts. The novel dosing methodology provides accurately preweighed tablets in virtually any shape and size and with excellent disintegration properties, speeding up parallel solution and solid phase synthesis. The use of tablets is demonstrated in parallel Mitsunobu and acylation reactions.Keywords
This publication has 14 references indexed in Scilit:
- Work-up strategies for high-throughput solution synthesisDrug Discovery Today, 2002
- Mitsunobu reaction modifications allowing product isolation without chromatography: application to a small parallel libraryTetrahedron Letters, 2000
- “Reactive Filtration”: Use of Functionalized Porous Polymer Monoliths as Scavengers in Solution-Phase SynthesisOrganic Letters, 1999
- Carbon-carbon bond formation on solid support: Synthesis of monoacyl piperazines by Knoevenagel-type condensation reactionsTetrahedron Letters, 1995
- Multiple peptide synthesis on acid‐labile handle derivatized polyethylene supportsInternational Journal of Peptide and Protein Research, 1994
- Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial LibrariesJournal of Medicinal Chemistry, 1994
- Inhibitors of human leukocyte proteinase-3Journal of Medicinal Chemistry, 1990
- Anticonvulsant Activity of Some 4-Methoxy- and 4-ChlorobenzanilidesJournal of Pharmaceutical Sciences, 1990
- Strategies for epitope analysis using peptide synthesisJournal of Immunological Methods, 1987
- General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.Proceedings of the National Academy of Sciences of the United States of America, 1985