The human hippocampus at 7 T—In vivo MRI
- 25 August 2008
- journal article
- research article
- Published by Wiley in Hippocampus
- Vol. 19 (1), 1-7
- https://doi.org/10.1002/hipo.20487
Abstract
The human hippocampus plays a central role in various neuropsychiatric disorders, such as temporal lobe epilepsy (TLE), Alzheimer's dementia, mild cognitive impairment, and schizophrenia. Its volume, morphology, inner structure, and function are of scientific and clinical interest. Magnetic resonance (MR) imaging is a widely employed tool in neuroradiological workup regarding changes in brain anatomy, (sub-) volumes, and cerebral function including the hippocampus. Gain in intrinsic MR signal provided by higher field strength scanners and concomitant improvements in spatial resolution seem highly valuable. An examination protocol permitting complete, high-resolution imaging of the human hippocampus at 7 T was implemented. Coronal proton density, T2, T2*, and fluid-attenuated inversion recovery contrasts were acquired as well as an isotropic 3D magnetization-prepared rapid acquisition gradient-echo (500 μm isotropic voxel dimension, noninterpolated). Observance of energy deposition restrictions within acceptable scan times remained challenging in the acquisition of thin, spin-echo-based sections. At the higher resolution enabled by 7 T, demarcation of the hippocampus and some internal features including gray/white matter differentiation and depiction of the hippocampal mantle becomes much more viable when compared with 1.5 T; thus, in the future, this imaging technology might help in the diagnosis of subtle hippocampal changes.This publication has 30 references indexed in Scilit:
- T2 Relaxometry of the Hippocampus at 3TAmerican Journal Of Neuroradiology, 2007
- High‐resolution 8 Tesla imaging of the formalin‐fixed normal human hippocampusClinical Anatomy, 2005
- Limits of 8-Tesla magnetic resonance imaging spatial resolution of the deoxygenated cerebral microvasculatureJournal of Magnetic Resonance Imaging, 2004
- Comparison of methods for measuring longitudinal brain change in cognitive impairment and dementiaNeurobiology of Aging, 2002
- Patterns of Cerebral Atrophy in Dementia with Lewy Bodies Using Voxel-Based MorphometryNeuroImage, 2002
- A Comparison of Medial and Lateral Temporal Lobe Atrophy in Dementia with Lewy Bodies and Alzheimer’s Disease: Magnetic Resonance Imaging Volumetric StudyDementia and Geriatric Cognitive Disorders, 2001
- MRI volumetric study of dementia with Lewy bodiesNeurology, 2000
- High Resolution MRI of the Deep Brain Vascular Anatomy at 8 Tesla: Susceptibility-Based Enhancement of the Venous StructuresJournal of Computer Assisted Tomography, 1999
- High Resolution MRI of the Deep Gray Nuclei at 8 TeslaJournal of Computer Assisted Tomography, 1999
- Intelligence and brain structure in normal individualsAmerican Journal of Psychiatry, 1993