Why does the immune system of Atlantic cod lack MHC II?
Open Access
- 13 April 2012
- Vol. 34 (8), 648-651
- https://doi.org/10.1002/bies.201200005
Abstract
MHC II, a major feature of the adaptive immune system, is lacking in Atlantic cod, and there are different scenarios (metabolic cost hypothesis or functional shift hypothesis) that might explain this loss. The lack of MHC II coincides with an increased number of genes for MHC I and Toll-like receptors (TLRs).This publication has 29 references indexed in Scilit:
- The genome sequence of Atlantic cod reveals a unique immune systemNature, 2011
- The origins of vertebrate adaptive immunityNature Reviews Immunology, 2010
- Immunological Control of Fish DiseasesMarine Biotechnology, 2010
- Origin and evolution of the adaptive immune system: genetic events and selective pressuresNature Reviews Genetics, 2009
- Genomic analysis of the immune gene repertoire of amphioxus reveals extraordinary innate complexity and diversityGenome Research, 2008
- The immune gene repertoire encoded in the purple sea urchin genomeDevelopmental Biology, 2006
- Genomic Insights into the Immune System of the Sea UrchinScience, 2006
- Ontogeny of the immune system of fishFish & Shellfish Immunology, 2006
- Comparative genomics of major histocompatibility complexesImmunogenetics, 2004
- Vaccination experiments and studies of the humoral immune responses in cod, Gadus morhua L., to four strains of monoclonal‐defined Vibrio anguillarumJournal of Fish Diseases, 1991