Strategies for reducing respiratory motion artifacts in renal perfusion imaging with arterial spin labeling
Open Access
- 24 March 2009
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 61 (6), 1374-1387
- https://doi.org/10.1002/mrm.21960
Abstract
Arterial spin labeling (ASL) perfusion measurements may have many applications outside the brain. In the abdomen, severe image artifacts can arise from motions between acquisitions of multiple signal averages in ASL, even with single‐shot image acquisition. Background suppression and respiratory motion synchronization techniques can be used to ameliorate these artifacts. Two separate in vivo studies of renal perfusion imaging using pulsed continuous ASL (pCASL) were performed. The first study assessed various combinations of background suppression and breathing strategies. The second investigated the retrospective sorting of images acquired during free breathing based on respiratory position. Quantitative assessments of the test‐retest repeatability of perfusion measurements and the image quality scored by two radiologists were made. Image quality was most significantly improved by using background suppression schemes and controlled breathing when compared to other combinations without background suppression or with free breathing, assessed by test‐retests (5% level, F‐test), and by radiologists' scores (5% level, Mann‐Whitney U‐test). Under free breathing, retrospectively sorting images based on respiratory position showed significant improvement. Both radiologists found 100% of the images had preferable image sharpness after sorting. High‐quality renal perfusion measurements with reduced respiratory motion artifacts have been demonstrated using ASL when appropriate background suppression and breathing strategies are applied. Magn Reson Med, 2009.Keywords
This publication has 59 references indexed in Scilit:
- Continuous flow‐driven inversion for arterial spin labeling using pulsed radio frequency and gradient fieldsMagnetic Resonance in Medicine, 2008
- Magnetic Resonance Imaging–Measured Blood Flow Change after Antiangiogenic Therapy with PTK787/ZK 222584 Correlates with Clinical Outcome in Metastatic Renal Cell CarcinomaClinical Cancer Research, 2008
- Technological advances in MRI measurement of brain perfusionJournal of Magnetic Resonance Imaging, 2005
- Efficiency of inversion pulses for background suppressed arterial spin labelingMagnetic Resonance in Medicine, 2005
- Magnetic resonance measurements of renal blood flow as a marker of disease severity in autosomal-dominant polycystic kidney disease11Thomas Andreoli, M.D., served as Guest Editor for this paper.Kidney International, 2003
- Assessment of cerebral blood flow in Alzheimer's disease by spin-labeled magnetic resonance imagingAnnals of Neurology, 2000
- Magnetic resonance imaging of the brain: Blood partition coefficient for water: Application to spin‐tagging measurement of perfusionJournal of Magnetic Resonance Imaging, 1996
- Homodyne detection in magnetic resonance imagingIEEE Transactions on Medical Imaging, 1991
- Frequency‐modulated radiofrequency pulses in spin‐echo and stimulated‐echo experimentsMagnetic Resonance in Medicine, 1987
- Highly selective π2 and π pulse generationJournal of Magnetic Resonance (1969), 1984