Oligofructose stimulates calcium absorption in adolescents

Abstract

Background: In rats, nondigestible oligosaccharides stimulate calcium absorption. Recently, this effect was also found in human subjects. Objective: The objective of the study was to investigate whether consumption of 15 g oligofructose/d stimulates calcium absorption in male adolescents. Design: Twelve healthy, male adolescents aged 14–16 y received, for 9 d, 15 g oligofructose or sucrose (control treatment) daily over 3 main meals. The treatments were given according to a randomized, double-blind, crossover design, separated by a 19-d washout period. On the 8th day of each treatment period, ⁴⁴Ca was given orally with a standard breakfast containing ≈200 mg Ca. Within half an hour after administration of ⁴⁴Ca, ⁴⁸Ca was administered intravenously. Fractional calcium absorption was computed from the enrichment of ⁴⁴Ca:⁴³Ca and ⁴⁸Ca:⁴³Ca in 36-h urine samples, which was measured by inductively coupled plasma mass spectrometry. Results: An increase in true fractional calcium absorption (%) was found after consumption of oligofructose (mean difference ± SE of difference: 10.8 ± 5.6; P < 0.05, one sided). The results are discussed in relation to the methods used. Conclusion: Fifteen grams of oligofructose per day stimulates fractional calcium absorption in male adolescents.