Long‐term results of a prospective study on the treatment of medulloblastoma in adults
Open Access
- 18 October 2007
- Vol. 110 (9), 2035-2041
- https://doi.org/10.1002/cncr.23003
Abstract
BACKGROUND. Because medulloblastoma (MB) is rare in adults, the few studies on this condition have been retrospective, and the follow-up has tended to be short. Furthermore, the different therapeutic strategies used in these patients has made it difficult to assess survival rates and prognostic factors. METHODS. In 1989, a prospective Phase II trial was initiated to evaluate the efficacy of treatment for adults with MB. Patients were staged completely with a neuroradiologic examination of the brain and neuroaxis and by cerebrospinal fluid cytology, according to Chang's staging system. Low-risk patients received radiotherapy alone, whereas high-risk patients received 2 cycles of upfront chemotherapy followed by radiotherapy and adjuvant chemotherapy. The current article reports on the long-term results from that trial. RESULTS. After a median follow up of 7.6 years, among a total of 36 adults with MB, the overall progression-free survival (PFS) and overall survival (OS) rates at 5 years were 72% and 75%, respectively. In low-risk patients, the 5-year PFS rate was 80%, and the 5-year OS rate was 80%; in high-risk patients, the 5-year PFS rate was 69%, and the 5-year OS rate was 73%. CONCLUSIONS. In adult patients with MB, long-term follow-up was essential for evaluating the real impact of treatments. Low-risk and high-risk patients did not differ significantly in terms of PFS or OS. Cancer 2007. © 2007 American Cancer Society.Keywords
This publication has 18 references indexed in Scilit:
- Phase III Study of Craniospinal Radiation Therapy Followed by Adjuvant Chemotherapy for Newly Diagnosed Average-Risk MedulloblastomaJournal of Clinical Oncology, 2006
- Review of the prognostic factors in medulloblastoma of children and adultsCritical Reviews in Oncology/Hematology, 2004
- Results of a Randomized Study of Preradiation Chemotherapy Versus Radiotherapy Alone for Nonmetastatic Medulloblastoma: The International Society of Paediatric Oncology/United Kingdom Children’s Cancer Study Group PNET-3 StudyJournal of Clinical Oncology, 2003
- Adult medulloblastoma: Multiagent chemotherapyNeuro-Oncology, 2001
- Adult Medulloblastoma: Prognostic Factors and Patterns of RelapseNeurosurgery, 2000
- Medulloblastoma in adults: clinical characteristics and treatmentCancer Treatment Reviews, 1999
- Prospective randomised trial of chemotherapy given before radiotherapy in childhood medulloblastoma. International society of paediatric oncology (SIOP) and the (German) society of paediatric oncology (GPO): SIOP IIMedical and Pediatric Oncology, 1995
- Medulloblastoma in adultsInternational Journal of Radiation Oncology*Biology*Physics, 1995
- Medulloblastoma in adults: Survival and prognostic factorsRadiotherapy and Oncology, 1993
- An Operative Staging System and a Megavoltage Radiotherapeutic Technic for Cerebellar MedulloblastomasRadiology, 1969