The excludon: a new concept in bacterial antisense RNA-mediated gene regulation
- 24 December 2012
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Microbiology
- Vol. 11 (2), 75-82
- https://doi.org/10.1038/nrmicro2934
Abstract
In recent years, non-coding RNAs have emerged as key regulators of gene expression. Among these RNAs, the antisense RNAs (asRNAs) are particularly abundant, but in most cases the function and mechanism of action for a particular asRNA remains elusive. Here, we highlight a recently discovered paradigm termed the excludon, which defines a genomic locus encoding an unusually long asRNA that spans divergent genes or operons with related or opposing functions. Because these asRNAs can inhibit the expression of one operon while functioning as an mRNA for the adjacent operon, they act as fine-tuning regulatory switches in bacteria.Keywords
This publication has 51 references indexed in Scilit:
- Condition-Dependent Transcriptome Reveals High-Level Regulatory Architecture in Bacillus subtilisScience, 2012
- RNase III Participates in GadY-Dependent Cleavage of the gadX-gadW mRNAJournal of Molecular Biology, 2011
- The intracellular sRNA transcriptome of Listeria monocytogenes during growth in macrophagesNucleic Acids Research, 2011
- The critical role of RNA processing and degradation in the control of gene expressionFEMS Microbiology Reviews, 2010
- Integrating anaerobic/aerobic sensing and the general stress response through the ArcZ small RNAThe EMBO Journal, 2010
- Transcriptome Complexity in a Genome-Reduced BacteriumScience, 2009
- CRISPR — a widespread system that provides acquired resistance against phages in bacteria and archaeaNature Reviews Microbiology, 2008
- Translational control of IS10 transpositionCell, 1983
- Promoter occlusion: Transcription through a promoter may inhibit its activityCell, 1982
- Genetic regulatory mechanisms in the synthesis of proteinsJournal of Molecular Biology, 1961