ASSESSMENT OF EARLY OSTEOARTHRITIS IN HIP DYSPLASIA WITH DELAYED GADOLINIUM-ENHANCED MAGNETIC RESONANCE IMAGING OF CARTILAGE
- 1 October 2003
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in The Journal of Bone and Joint Surgery-American Volume
- Vol. 85 (10), 1987-1992
- https://doi.org/10.2106/00004623-200310000-00019
Abstract
The efficacy of surgical and medical treatment of osteoarthritis is difficult to assess because of the lack of a noninvasive, sensitive measure of cartilage integrity. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) was designed to specifically examine glycosaminoglycan changes in articular cartilage that occur during the development of osteoarthritis. Our primary goal was to compare this technique with measurement of the joint space width on conventional radiographs in patients with hip dysplasia. We performed this comparison by assessing the correlation between the findings of each technique and clinically important factors such as pain, severity of dysplasia, and age. Sixty-eight hips in forty-three patients were included in the study. Clinical symptoms were assessed with use of the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) questionnaire. The width of the joint space as well as the lateral center-edge angle of Wiberg (as a measure of the severity of the dysplasia) was measured on standard standing radiographs. Magnetic resonance imaging maps of glycosaminoglycan distribution were made with T1-calculated images after administration of gadopentetate2- (Gd-DTPA2-). The dGEMRIC index was calculated as the average of the T1 values for the acetabular and femoral head cartilages. The dGEMRIC index correlated with both pain (rs = −0.50, p s We demonstrated that, in patients with hip dysplasia, the dGEMRIC index—a measure of the biochemical integrity of cartilage—correlates with pain and the severity of the dysplasia and is significantly different among groups of hips with mild, moderate, and severe dysplasia, suggesting that it may be a sensitive measure of early osteoarthritis. Additional studies are needed to determine whether dGEMRIC can be used to predict disease progression in different situations and/or demonstrate responses to therapeutic interventions.Keywords
This publication has 13 references indexed in Scilit:
- Gd‐DTPA2–‐enhanced MRI of femoral knee cartilage: A dose‐response study in healthy volunteersMagnetic Resonance in Medicine, 2001
- Protocol issues for delayed Gd(DTPA)2--enhanced MRI (dGEMRIC) for clinical evaluation of articular cartilageMagnetic Resonance in Medicine, 2001
- The role of relaxation times in monitoring proteoglycan depletion in articular cartilageJournal of Magnetic Resonance Imaging, 1999
- Clinical trials design: structure modifying agents for osteoarthritis. Future guidelines: areas for developmentOsteoarthritis and Cartilage, 1999
- Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRIMagnetic Resonance in Medicine, 1999
- Glycosaminoglycan in articular cartilage: in vivo assessment with delayed Gd(DTPA)(2-)-enhanced MR imaging.Radiology, 1997
- Gd‐DTPA2− as a measure of cartilage degradationMagnetic Resonance in Medicine, 1996
- The prognosis in untreated dysplasia of the hip. A study of radiographic factors that predict the outcome.The Journal of Bone & Joint Surgery, 1995
- Radiographic assessment of progression in osteoarthritisArthritis & Rheumatism, 1987
- Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. I. Chemical composition.Annals Of The Rheumatic Diseases, 1977