Antifertility Activity ofQuassia amara: Quassin Inhibits the Steroidogenesis in Rat Leydig CellsIn Vitro

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Abstract
The crude methanol extract of the stem wood of Quassia amara L. inhibited both the basal and LH-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion. Fractionation of the extract by chromatography gave quassin (1) and 2-methoxycanthin-6-one (2); compound 1 proved to be the bioactive agent.