Cytogenetic Studies in Rats of Cyclohexylamine, a Metabolite of Cyclamate
- 12 September 1969
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 165 (3898), 1139-1140
- https://doi.org/10.1126/science.165.3898.1139
Abstract
Cyclohexylamine, the major known metabolite of cyclamate, was tested in vivo for possible cytogenetic effects. In rats injected with this metabolite, there was a direct relation between dose concentration and percentage of spermatogonial and bone marrow cells showing chromosomal breaks. Single chromatid breaks predominated with infrequent exchange figures.Keywords
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