Characterization of a Cell-Lethal Product from the Photooxidation of Tryptophan: Hydrogen Peroxide
- 6 February 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 191 (4226), 468-469
- https://doi.org/10.1126/science.1108203
Abstract
Near-ultraviolet (300 to 400 nanometers) irradiation of saturated, oxygenated solutions of tryptophan in the absence of added sensitizer gives rise to substances that have various biological effects on isolated cells, including mutagenicity and selective lethality to recombination-deficient bacterial mutants. One of these biologically active products has been identified as H2O2, on the basis of spectrometric, chromatographic, chemical, and biological properties. Now H2O2 has been shown to account for the biological activities mentioned above.Keywords
This publication has 10 references indexed in Scilit:
- Tryptophan photoproduct(s): sensitized induction of strand breaks (or alkali-labile bonds) in bacterial deoxyribonucleic acid during near-ultraviolet irradiationJournal of Bacteriology, 1975
- PHOTOSENSITIZED SPLITTING OF PYRIMIDINE DIMERS IN DNA BY INDOLE DERIVATIVES AND TRYPTOPHAN‐CONTAINING PEPTIDESPhotochemistry and Photobiology, 1975
- Effect of Near-Ultraviolet and Visible Light on Mammalian Cells in Culture II. Formation of Toxic Photoproducts in Tissue Culture Medium by BlacklightProceedings of the National Academy of Sciences of the United States of America, 1974
- Inhibition of Replication Gap Closure in Escherichia coli by Near-Ultraviolet Light Photoproducts of l -TryptophanJournal of Bacteriology, 1974
- N‐FORMYL‐KYNURENINE, A TRYPTOPHAN PHOTOOXIDATION PRODUCT, AS A PHOTODYNAMIC SENSITIZERPhotochemistry and Photobiology, 1974
- The binding of photo-oxidized tryptophan to a lens gamma-crystallinExperimental Eye Research, 1973
- THE PHOTOLYSIS OF TRYPTOPHAN IN THE PRESENCE OF OXYGENPhotochemistry and Photobiology, 1973
- THE DESTRUCTION OF TRYPTOPHANYL RESIDUES IN TRYPSIN BY 280‐nm RADIATIONPhotochemistry and Photobiology, 1973
- Occurrence of 3- O -(β- d -Glucopyranosyluronic Acid)- d -Galactose in the Capsular Polysaccharide of Klebsiella K-Type 20Journal of Bacteriology, 1972
- Isolation and identification of some photo-oxidation products of tryptophanAustralian Journal of Chemistry, 1971