In Vitro Activities at pH 5.0 and pH 7.0 and In Vivo Efficacy of Flucytosine against Aspergillus fumigatus
- 1 December 2008
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 52 (12), 4483-4485
- https://doi.org/10.1128/aac.00491-08
Abstract
The antifungal agent flucytosine was found to be active in vitro against Aspergillus fumigatus isolates when the MIC was determined at pH 5.0 instead of pH 7.0. The in vitro MIC at pH 5.0 corresponded to the in vivo efficacy of flucytosine monotherapy in a murine model of invasive aspergillosis.Keywords
This publication has 11 references indexed in Scilit:
- Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of AmericaClinical Infectious Diseases, 2008
- Recommendations for managing Aspergillus osteomyelitis and joint infections based on a review of the literatureJournal of Infection, 2006
- Efficacy and Pharmacodynamics of Flucytosine Monotherapy in a Nonneutropenic Murine Model of Invasive AspergillosisAntimicrobial Agents and Chemotherapy, 2005
- Effect of pH on the In Vitro Activities of Amphotericin B, Itraconazole, and Flucytosine against Aspergillus IsolatesAntimicrobial Agents and Chemotherapy, 2004
- Treatment of fungal infections in hematology and oncologyAnnals of Hematology, 2003
- Flucytosine and Cryptococcosis: WhichIn VitroTest Is the Best Predictor of Outcome?Journal of Chemotherapy, 2003
- Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactionsJournal of Antimicrobial Chemotherapy, 2000
- Amphotericin B versus amphotericin B plus 5-flucytosine: Poor results in the treatment of proven systemic mycoses in neutropenic patientsInfection, 1994
- Purine–cytosine permease of Saccharomyces cerevisiaeEuropean Journal of Biochemistry, 1992
- On the Mechanism of Substrate Binding to the Purine‐Transport System of Saccharomyces cerevisiaeEuropean Journal of Biochemistry, 1978