PDF file - 526K, FDG-uptake and CT-PET scanning of mice before and after 2 weeks of treatment with NVP-BKM120. Tumor-bearing female MMTV-CreBRCA1f/fp53+/- mice were imaged with PET-CT scans before and after treatments with NVP-BKM120 at 50 mg/kg/day. Yellow arrows in the upper panel point to the dominant mass in each mouse before treatment. Synchronous additional tumors are indicated with green arrows. The lower panel displays the same mice imaged within 3 hours of treatment with a two-week course of NVP-BKM120 at 50 mg/kg/day. Percent decrease of FDG-uptake in the dominant mass was determined as described in Materials and Methods