Cancer hyperthermia using magnetic nanoparticles
- 26 August 2011
- journal article
- review article
- Published by Wiley in Biotechnology Journal
- Vol. 6 (11), 1342-1347
- https://doi.org/10.1002/biot.201100045
Abstract
Magnetic‐nanoparticle‐mediated intracellular hyperthermia has the potential to achieve localized tumor heating without any side effects. The technique consists of targeting magnetic nanoparticles to tumor tissue followed by application of an external alternating magnetic field that induces heat through Néel relaxation loss of the magnetic nanoparticles. The temperature in tumor tissue is increased to above 43°C, which causes necrosis of cancer cells, but does not damage surrounding normal tissue. Among magnetic nanoparticles available, magnetite has been extensively studied. Recent years have seen remarkable advances in magnetite‐nanoparticle‐mediated hyperthermia; both functional magnetite nanoparticles and alternating‐magnetic‐field generators have been developed. In addition to the expected tumor cell death, hyperthermia treatment has also induced unexpected biological responses, such as tumor‐specific immune responses as a result of heat‐shock protein expression. These results suggest that hyperthermia is able to kill not only local tumors exposed to heat treatment, but also tumors at distant sites, including metastatic cancer cells. Currently, several research centers have begun clinical trials with promising results, suggesting that the time may have come for clinical applications. This review describes recent advances in magnetite nanoparticle‐mediated hyperthermia.Keywords
This publication has 18 references indexed in Scilit:
- Fundamental Studies of Hyperthermia Using Magnetic Particles as Thermo-seeds: 1: Development of Magnetic Particles Suitable for HyperthermiaJournal of the Magnetics Society of Japan, 2006
- Magnetite nanoparticle-loaded anti-HER2 immunoliposomes for combination of antibody therapy with hyperthermiaCancer Letters, 2004
- Complete regression of mouse mammary carcinoma with a size greater than 15 mm by frequent repeated hyperthermia using magnetite nanoparticlesJournal of Bioscience and Bioengineering, 2003
- Applications of magnetic nanoparticles in biomedicineJournal of Physics D: Applied Physics, 2003
- Targeting Hyperthermia for Renal Cell Carcinoma Using Human MN Antigenspecific MagnetoliposomesJapanese Journal of Cancer Research, 2001
- Intracellular Hyperthermia for Cancer Using Magnetite Cationic Liposomes: In vitro StudyJapanese Journal of Cancer Research, 1996
- Antibody‐conjugated magnetoliposomes for targeting cancer cells and their application in hyperthermiaBiotechnology and Applied Biochemistry, 1995
- Development of intra-arterial hyperthermia using a dextran-magnetite complexInternational Journal of Hyperthermia, 1994
- Inductive heating of ferrimagnetic particles and magnetic fluids: Physical evaluation of their potential for hyperthermiaInternational Journal of Hyperthermia, 1993
- Intracellular hyperthermia a biophysical approach to cancer treatment via intracellular temperature and biophysical alterationsMedical Hypotheses, 1979