Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health
- 23 October 2013
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 110 (46), 18360-18367
- https://doi.org/10.1073/pnas.1313731110
Abstract
Epidemiological studies suggest that living close to the natural environment is associated with long-term health benefits including reduced death rates, reduced cardiovascular disease, and reduced psychiatric problems. This is often attributed to psychological mechanisms, boosted by exercise, social interactions, and sunlight. Compared with urban environments, exposure to green spaces does indeed trigger rapid psychological, physiological, and endocrinological effects. However, there is little evidence that these rapid transient effects cause long-term health benefits or even that they are a specific property of natural environments. Meanwhile, the illnesses that are increasing in high-income countries are associated with failing immunoregulation and poorly regulated inflammatory responses, manifested as chronically raised C-reactive protein and proinflammatory cytokines. This failure of immunoregulation is partly attributable to a lack of exposure to organisms ("Old Friends") from mankind's evolutionary past that needed to be tolerated and therefore evolved roles in driving immunoregulatory mechanisms. Some Old Friends (such as helminths and infections picked up at birth that established carrier states) are almost eliminated from the urban environment. This increases our dependence on Old Friends derived from our mothers, other people, animals, and the environment. It is suggested that the requirement for microbial input from the environment to drive immunoregulation is a major component of the beneficial effect of green space, and a neglected ecosystem service that is essential for our well-being. This insight will allow green spaces to be designed to optimize health benefits and will provide impetus from health systems for the preservation of ecosystem biodiversity.Keywords
This publication has 136 references indexed in Scilit:
- Home Life: Factors Structuring the Bacterial Diversity Found within and between HomesPLOS ONE, 2013
- Cohabiting family members share microbiota with one another and with their dogseLife, 2013
- Significant changes in the skin microbiome mediated by the sport of roller derbyPeerJ, 2013
- NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for ColitisCell, 2011
- Man's best friend? The effect of pet ownership on house dust microbial communitiesJournal of Allergy and Clinical Immunology, 2010
- Repeated bouts of aerobic exercise enhance regulatory T cell responses in a murine asthma modelBrain, Behavior, and Immunity, 2010
- Trends in research related to “Shinrin-yoku” (taking in the forest atmosphere or forest bathing) in JapanEnvironmental Health and Preventive Medicine, 2009
- The physiological effects of Shinrin-yoku (taking in the forest atmosphere or forest bathing): evidence from field experiments in 24 forests across JapanEnvironmental Health and Preventive Medicine, 2009
- Florida red tide and human health: A pilot beach conditions reporting system to minimize human exposureScience of The Total Environment, 2008
- Identification of an immune-responsive mesolimbocortical serotonergic system: Potential role in regulation of emotional behaviorNeuroscience, 2007