SIRT6: A Promising Target for Cancer Prevention and Therapy
- 16 June 2014
- book chapter
- review article
- Published by Springer Science and Business Media LLC
- Vol. 818, 181-196
- https://doi.org/10.1007/978-1-4471-6458-6_9
Abstract
Many of the pathologies associated with the aging process also contribute to tumor initiation, growth or metastasis. Insights from biogerontology may be instrumental for developing new therapies for cancer. This chapter highlights the rationale for combining biogerontology and cancer research to generate new strategies for cancer treatment. In particular, this chapter focuses on one gene, SIRT6, which has emerged as an important regulator of longevity in mammals and appears to have multiple biochemical functions, which antagonize tumor development and may be useful in cancer prevention and treatment.Keywords
This publication has 75 references indexed in Scilit:
- Hallmarks of Cancer: The Next GenerationCell, 2011
- Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric RestrictionCell, 2010
- RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10Cell, 2010
- The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1αCell, 2010
- SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life SpanCell, 2009
- Impact of aging on the biology of breast cancerCritical Reviews in Oncology/Hematology, 2008
- Regulation of SIRT6 protein levels by nutrient availabilityFEBS Letters, 2008
- Extension of mouse lifespan by overexpression of catalaseAGE, 2006
- Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanNature, 2003
- The Hallmarks of CancerCell, 2000