Contributions of Quisqualate and NMDA Receptors to the Induction and Expression of LTP
- 23 December 1988
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 242 (4886), 1694-1697
- https://doi.org/10.1126/science.2904701
Abstract
The contributions of two subclasses of excitatory amino acid transmitter receptors to the induction and expression of long-term potentiation (LTP) were analyzed in hippocampal slices. The quisqualate/kainate receptor antagonist DNQX (6,7-dinitro-quinoxaline-2,3-dione) blocked 85% of the evoked field potential, leaving a small response that was sensitive to D-AP5 (D-2-amino-5-phosphonopentanoate), an N-methyl-D-aspartate (NMDA) receptor blocker. This residual D-AP5-sensitive response was of comparable size in control and previously potentiated inputs. High-frequency stimulation in the presence of DNQX did not result in the development of robust LTP. Washout of the drug, however, revealed the potentiation effect. Thus NMDA-mediated responses can induce, but are not greatly affected by, LTP; non-NMDA receptors, conversely, mediate responses that are not needed to elicit LTP but that are required for its expression.This publication has 19 references indexed in Scilit:
- The NMDA receptor-mediated components of responses evoked by patterned stimulation are not increased by long-term potentiationBrain Research, 1989
- Rate‐limiting step for transmission at excitatory synapses in hippocampusSynapse, 1989
- Quinoxalinediones: Potent Competitive Non-NMDA Glutamate Receptor AntagonistsScience, 1988
- Role of
methyl- receptors in the induction of synaptic potentiation by burst stimulation patterned after the hippocampal θ-rhythmD -aspartateBrain Research, 1988 - Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanismNature, 1986
- Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5Nature, 1986
- Transient and enduring morphological correlates of synaptic activity and efficacy change in the rat hippocampal sliceBrain Research, 1984
- Magnesium gates glutamate-activated channels in mouse central neuronesNature, 1984
- Long-term potentiation of the perforant path in vivo is associated with increased glutamate releaseNature, 1982
- Synaptic enhancement in fascia dentata: Cooperativity among coactive afferentsBrain Research, 1978