SARS-CoV-2: a storm is raging
Open Access
- 1 May 2020
- journal article
- editorial
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 130 (5), 2202-2205
- https://doi.org/10.1172/jci137647
Abstract
The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunologic characteristics between moderate versus severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10 and TNFα), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFNγ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.This publication has 19 references indexed in Scilit:
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