Role of Emerging Environmental Risk Factors in Thyroid Cancer: A Brief Review
Open Access
- 2 April 2019
- journal article
- review article
- Published by MDPI AG in International Journal of Environmental Research and Public Health
- Vol. 16 (7), 1185
- https://doi.org/10.3390/ijerph16071185
Abstract
Environmental factors are recognized as risk factors of thyroid cancer in humans. Exposure to radiation, both from nuclear weapon or fallout or medical radiation, and to some organic and inorganic chemical toxicants represent a worldwide public health issue for their proven carcinogenicity. Halogenated compounds, such as organochlorines and pesticides, are able to disrupt thyroid function. Polychlorinated biphenyls and their metabolites and polybrominated diethyl ethers bind to thyroid, transport proteins, replace thyroxin, and disrupt thyroid function as phthalates and bisphenolates do, highly mimicking thyroid hormones. A better knowledge of environmental risks represents a very important tool for cancer prevention through true risks prevention and management. This approach is very important because of the epigenetic origin’s theory of cancer. Therefore, the aim of this review was study the association between environmental agents and thyroid cancer promotion.Funding Information
- Department of Medical, Surgical and Advanced Technologies, University of Catania (intradepartmental research plan 2016/2018 - number 5C722012104, 2018)
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