Defining age limits of the sensitive period for attachment learning in rat pups
- 29 June 2010
- journal article
- research article
- Published by Wiley in Developmental Psychobiology
- Vol. 52 (5), 453-464
- https://doi.org/10.1002/dev.20448
Abstract
Enhanced odor preference learning and attenuated fear learning characterizes rat pups' attachment learning Sensitive Period for learning the maternal odor. This period terminates at 10 days old (PN10) with increasing endogenous levels of the stress hormone, corticosterone. Increasing Sensitive Period pups' corticosterone prematurely terminates the Sensitive Period, while decreasing corticosterone in older pups delays Sensitive Period termination. Here we extend these findings and define the age range corticosterone alters learning and question whether corticosterone permanently terminates the Sensitive Period. Pups were odor‐0.5 mA shock conditioned with either corticosterone increased (PN5–6; 4 mg/kg vs. saline) or decreased (PN15–16; naturally by maternal presence or corticosterone synthesis blocker, Metyrapone). Finally, PN7–8 pups were conditioned with corticosterone and reconditioned without corticosterone to assess whether the Sensitive Period was permanently terminated. Results indicate developmental limits for corticosterone regulation of pup learning are PN6 through PN15. Furthermore, inducing precocious corticosterone induced fear learning was not permanent, since reconditioning without corticosterone enabled odor preference learning. Results suggest pups are protected from learning aversions to maternal odor until approaching weaning. © 2010 Wiley Periodicals, Inc. Dev Psychobiol 52: 453–460, 2010.Keywords
This publication has 137 references indexed in Scilit:
- Transitions in infant learning are modulated by dopamine in the amygdalaNature Neuroscience, 2009
- Ontogeny of odor-LiCl vs. odor-shock learning: Similar behaviors but divergent ages of functional amygdala emergenceLearning & Memory, 2009
- Noradrenergic neuromodulation in the olfactory bulb modulates odor habituation and spontaneous discrimination.Behavioral Neuroscience, 2008
- Maternal attenuation of hypothalamic paraventricular nucleus norepinephrine switches avoidance learning to preference learning in preweanling rat pupsHormones and Behavior, 2007
- Development switch in neural circuitry underlying odor-malaise learningLearning & Memory, 2006
- Programming social, cognitive, and neuroendocrine development by early exposure to noveltyProceedings of the National Academy of Sciences, 2006
- Maternal presence serves as a switch between learning fear and attraction in infancyNature Neuroscience, 2006
- Dual Circuitry for Odor-Shock Conditioning during Infancy: Corticosterone Switches between Fear and Attraction via AmygdalaJournal of Neuroscience, 2006
- CRITICAL PERIOD REGULATIONAnnual Review of Neuroscience, 2004
- Ontogeny of Type I and Type II corticosteroid receptors in the rat hippocampusDevelopmental Brain Research, 1988