The AP‐1/CJUN signaling cascade is involved in muscle differentiation: Implications in muscle wasting during cancer cachexia
- 5 January 2006
- journal article
- Published by Wiley in FEBS Letters
- Vol. 580 (2), 691-696
- https://doi.org/10.1016/j.febslet.2005.12.084
Abstract
The aim of the present study was to investigate a possible role of the AP-1 signaling cascade in the process of wasting associated with cancer cachexia at the level of skeletal muscle. The injection of virus containing the TAM67 protein (a blocker of the AP-1 protein) to the gastrocnemius muscle of tumour-bearing rats resulted in a significant recovery of the muscle mass (which is dramatically reduced as a result of tumour burden), therefore suggesting that AP-1 is certainly involved in the signaling associated with muscle protein accretion. In conclusion, the gene therapy approach presented here clearly suggests an important role for AP-1 in muscle signaling during catabolic statesKeywords
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