Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes
- 14 October 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Chemical Biology
- Vol. 8 (12), 957-959
- https://doi.org/10.1038/nchembio.1091
Abstract
Methylation is among the most widespread chemical modifications encountered in biomolecules and has a pivotal role in many major biological processes. In the biosynthetic pathway of the antibiotic thiostrepton A, we identified what is to our knowledge the first tryptophan methyltransferase. We show that it uses unprecedented chemistry to methylate inactivated sp(2)-hybridized carbon atoms, despite being predicted to be a radical SAM enzyme.Keywords
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