The frequency of sacroiliitis in familial Mediterranean fever and the role of HLA-B27 and MEFV mutations in the development of sacroiliitis
- 16 September 2008
- journal article
- Published by Springer Science and Business Media LLC in Clinical Rheumatology
- Vol. 28 (1), 41-46
- https://doi.org/10.1007/s10067-008-0980-3
Abstract
The objective of this study was to investigate the frequency of sacroiliitis in familial Mediterranean fever (FMF) patients and the role of HLA-B27 and MEFV mutations in the development of sacroiliitis. The study group consisted of 256 FMF patients (male 128, female 128, mean age 27.2 +/- 6.3 years). After evaluation of the medical records, 70 patients (27.4%) were determined to have one or more of musculoskeletal manifestations. Sacroiliitis was determined in 18 (32.7%) FMF patients. The frequency of sacroiliitis among all FMF patients was found to be 7%. HLA-B27 was 47% and 6.3% in FMF patients with and without sacroiliitis, respectively. The frequency of M694V mutations in FMF patients with sacroiliitis was 93.7%. Sacroiliitis may be seen more frequently in FMF patients than expected. HLA-B27 positivity and/or M694V mutation may play a role in the development of sacroiliitis and the severity of seronegative spondyloarthropathy.This publication has 15 references indexed in Scilit:
- The diagnostic value of scintigraphy in assessing sacroiliitis in ankylosing spondylitis: a systematic literature researchAnnals Of The Rheumatic Diseases, 2008
- MEFV mutations in patients with familial Mediterranean fever in the Black Sea region of Turkey: Samsun experience [corrected].2007
- Familial Mediterranean fever and ankylosing spondylitis in a patient with juvenile idiopathic arthritis: a case report and review of the literatureRheumatology International, 2005
- Severe disease in patients with rheumatoid arthritis carrying a mutation in the Mediterranean fever geneAnnals Of The Rheumatic Diseases, 2005
- A comparison of clinical findings of familial Mediterranean fever patients with and without amyloidosisRheumatology International, 2004
- MEFV mutations in familial Mediterranean fever: association of M694V homozygosity with arthritisRheumatology International, 2004
- Familial Mediterranean Fever: Effects of Genotype and Ethnicity on Inflammatory Attacks and AmyloidosisPEDIATRICS, 2000
- Seronegative spondyloarthropathy in familial Mediterranean feverSeminars in Arthritis and Rheumatism, 1997
- Criteria for the diagnosis of familial mediterranean feverArthritis & Rheumatism, 1997
- Evaluation of Diagnostic Criteria for Ankylosing SpondylitisArthritis & Rheumatism, 1984