Investigating the Relationship between Serum Interleukin-17 Levels and Systemic Immune-Mediated Disease in Patients with Dry Eye Syndrome
Open Access
- 1 January 2011
- journal article
- research article
- Published by Korean Ophthalmological Society in Korean Journal of Ophthalmology
- Vol. 25 (2), 73-76
- https://doi.org/10.3341/kjo.2011.25.2.73
Abstract
To investigate the association between dry eye syndrome (DE) and serum levels of interleukin (IL)-17 in patients with systemic immune-mediated diseases. IL-17 and IL-23 levels were measured in the sera of patients whose tear production was <5 mm on the Schirmer test. Subjects included patients with chronic graft-versus-host disease (GVHD), rheumatoid arthritis (RA), Sjogren's syndrome (SS), systemic lupus erythematosus (SLE), and no systemic disease. Corneal/conjunctival fluorescein staining was scored and the correlation between the score and the IL-17 level was evaluated. A strong correlation existed between IL-17 level and the type of systemic disease. IL-17 was significantly elevated in patients with chronic GVHD compared to those with RA and SS. IL-17 was not detectable in patients with SLE or in those without systemic disease. IL-23 was not detected in any of the subjects. IL-17 was significantly increased in patients with high fluorescein staining scores. Our data suggest that IL-17 is involved in the pathogenesis of DE in patients with systemic immune-mediated diseases.Keywords
This publication has 18 references indexed in Scilit:
- Interleukin-23/Th17 pathways and inflammatory bowel diseaseInflammatory Bowel Diseases, 2009
- The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivoNature Immunology, 2009
- Cytokines that regulate autoimmunityCurrent Opinion in Immunology, 2008
- IL-17 and the Th17 lineage in systemic lupus erythematosusCurrent Opinion in Rheumatology, 2008
- Identification of IL-18 and Th17 Cells in Salivary Glands of Patients with Sjögren’s Syndrome, and Amplification of IL-17-Mediated Secretion of Inflammatory Cytokines from Salivary Gland Cells by IL-18Published by The American Association of Immunologists ,2008
- Upregulated IL-23 and IL-17 in Behçet Patients with Active UveitisInvestigative Opthalmology & Visual Science, 2008
- Th17 cells in human diseaseImmunological Reviews, 2008
- Salivary gland tissue expression of interleukin‐23 and interleukin‐17 in Sjögren's syndrome: Findings in humans and miceArthritis & Rheumatism, 2008
- TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1Nature Medicine, 2007
- IL-23 drives a pathogenic T cell population that induces autoimmune inflammationThe Journal of Experimental Medicine, 2005