Possible Association of Amelogenin to High Caries Experience in a Guatemalan-Mayan Population
- 27 November 2007
- journal article
- research article
- Published by S. Karger AG in Caries Research
- Vol. 42 (1), 8-13
- https://doi.org/10.1159/000111744
Abstract
There is evidence for a genetic component in caries susceptibility, but the disease is greatly influenced by environmental factors, which are extremely difficult to control in humans. For the present study, we used DNA samples collected from 110 unrelated, non-cleft individuals older than 12 years of age from Tiquisate, Guatemala: a population with similar cultural, dietary and hygiene habits, similar access to the dentist and fluoride exposure. Forty-four individuals were designated ‘very low caries experience’ (DMFT ≤2), and 66 were designated ‘higher caries experience’ (DMFT ≧3). Single-nucleotide polymorphism markers were genotyped in selected candidate genes (ameloblastin, amelogenin, enamelin, tuftelin-1, and tuftelin interacting protein 11) that influence enamel formation. Having at least one copy of the rare amelogenin marker allele was associated with increased age-adjusted caries experience. This association was stronger in individuals with higher DMFT (DMFT ≧20; p = 0.0000001). Our results suggest that variation in amelogenin may contribute to caries susceptibility in the population studied. The approach of comparing individuals with extremely distinct caries experiences could be valuable for decreasing the potential influence of environmental factors on genetic studies of caries.Keywords
This publication has 23 references indexed in Scilit:
- Predisposing Factors to Dental Caries in Children with Cleft Lip and Palate: A Review and Strategies for Early PreventionThe Cleft Palate Craniofacial Journal, 2007
- The molecular etiologies and associated phenotypes of amelogenesis imperfectaAmerican Journal of Medical Genetics Part A, 2006
- Explaining sex differences in dental caries prevalence: Saliva, hormones, and “life‐history” etiologiesAmerican Journal of Human Biology, 2006
- Identification of Chromosomes Associated with Dental Caries Susceptibility Using Quantitative Trait Locus Analysis in MiceCaries Research, 2004
- EditorialInternational Journal of Paediatric Dentistry, 2003
- Power of Linkage versus Association Analysis of Quantitative Traits, by Use of Variance-Components Models, for Sibship DataAmerican Journal of Human Genetics, 2000
- X Inactivation in Females with X-Linked DiseaseNew England Journal of Medicine, 1998
- A human X-Y homologous region encodes “amelogenin”Genomics, 1991
- Twin Half-sibs: A Research Design for Genetic Epidemiology of Common Dental DisordersJournal of Dental Research, 1990
- Inheritance of Susceptibility to Caries in Albino Rats (Mus Norvegicus)Journal of Dental Research, 1944