Supramolecular structure of 5-aminosalycilic acid/halloysite composites
- 20 October 2008
- journal article
- Published by Informa UK Limited in Journal of Microencapsulation
- Vol. 26 (3), 279-286
- https://doi.org/10.1080/02652040802312499
Abstract
This paper assesses the supramolecular structure of nanocomposites prepared by including the anti-inflammatory drug 5-aminosalycilic acid in halloysite nanotubes. Halloysite tubes have sub-micron individual lengths with outer diameters ∼0.1 µm, as observed by FESEM. The mercury intrusion plots showed bimodal profiles with pore dimensions ∼10 and 0.06 µm. X-ray diffraction and thermogravimetric results revealed changes in the hydration form of the clay after the interaction. The groups associated to the interaction were studied by FTIR. The location of the drug in the composites was determined after uranium staining of its amino groups by X-EDS microanalysis coupled with HREM. The drug was located both inside and on the surface of the halloysite nanotubes. These results confirm the occurrence of two concomitant interaction mechanisms: rapid adsorption of 5-ASA at the external halloysite surface followed by slow adsorption of the drug inside the tubes.Keywords
This publication has 14 references indexed in Scilit:
- Use of clays as drug delivery systems: Possibilities and limitationsApplied Clay Science, 2007
- Equilibrium and kinetics of 5-aminosalicylic acid adsorption by halloysiteMicroporous and Mesoporous Materials, 2007
- Differences in the Dehydration-Rehydration Behavior of Halloysites: New Evidence and InterpretationsClays and Clay Minerals, 2006
- Halloysite clay minerals — a reviewClay Minerals, 2005
- Use of porous aluminosilicate pellets for drug deliveryJournal of Microencapsulation, 2005
- Supramolecular structure of humic acids by TEM with improved sample preparation and stainingMicroscopy Research and Technique, 2005
- Application of a Single Model to Study the Adsorption Equilibrium of Prednisolone on Six Carbonaceous MaterialsJournal of Colloid and Interface Science, 2002
- Application of a Single Model to Study the Adsorption Kinetics of Prednisolone on Six Carbonaceous MaterialsJournal of Colloid and Interface Science, 2002
- Modification of Surface Charge Properties during Kaolinite to Halloysite-7Å TransformationJournal of Colloid and Interface Science, 1999
- ELECTRON STAINING WITH URANYL ACETATE POSSIBLE ROLE OF FREE AMINO GROUPSJournal of Histochemistry & Cytochemistry, 1971