Genetic Variance in the Adiponutrin Gene Family and Childhood Obesity
Open Access
- 24 April 2009
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 4 (4), e5327
- https://doi.org/10.1371/journal.pone.0005327
Abstract
The adiponutrin gene family consists of five genes (PNPLA1-5) coding for proteins with both lipolytic and lipogenic properties. PNPLA3 has previously been associated with adult obesity. Here we investigated the possible association between genetic variants in these genes and childhood and adolescent obesity. Polymorphisms in the five genes of the adiponutrin gene family were selected and genotyped using the Sequenom platform in a childhood and adolescent obesity case-control study. Six variants in PNPLA1 showed association with obesity (rs9380559, rs12212459, rs1467912, rs4713951, rs10947600, and rs12199580, p0.05). When analyzing these SNPs in relation to phenotypes, two SNPs in the PNPLA3 gene showed association with insulin sensitivity (rs12483959: β = −0.053, p = 0.016, and rs2072907: β = −0.049, p = 0.024). No associations were seen for PNPLA2, PNPLA4, and PNPLA5. Genetic variation in the adiponutrin gene family does not seem to contribute strongly to obesity in children and adolescents. PNPLA1 exhibited a modest effect on obesity and PNPLA3 on insulin sensitivity. These data, however, require confirmation in other cohorts and ethnic groups.This publication has 38 references indexed in Scilit:
- Common variants near MC4R are associated with fat mass, weight and risk of obesityNature Genetics, 2008
- Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypesBiochemical and Biophysical Research Communications, 2008
- Childhood Body-Mass Index and the Risk of Coronary Heart Disease in AdulthoodThe New England Journal of Medicine, 2007
- PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage AnalysesAmerican Journal of Human Genetics, 2007
- Variation in FTO contributes to childhood obesity and severe adult obesityNature Genetics, 2007
- A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult ObesityScience, 2007
- Haploview: analysis and visualization of LD and haplotype mapsBioinformatics, 2004
- The International HapMap ProjectNature, 2003
- The hormone-sensitive lipase gene and body composition: the HERITAGE Family StudyInternational Journal of Obesity, 2002
- Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approachDiabetes, 1989