Diminished Cerebral Inhibition in Neonates Associated With Risk Factors for Schizophrenia: Parental Psychosis, Maternal Depression, and Nicotine Use
- 19 April 2010
- journal article
- research article
- Published by Oxford University Press (OUP) in Schizophrenia Bulletin
- Vol. 37 (6), 1200-1208
- https://doi.org/10.1093/schbul/sbq036
Abstract
Diminished inhibitory gating of cerebral auditory evoked responses is transmitted in families with psychoses as an endophenotype related to the genetic risk for these illnesses. To assess whether the endophenotype is already expressed in infants of parents with psychotic illness and to assess effects of other known risk factors for schizophrenia, ie, maternal cigarette smoking and depression, inhibitory gating of cerebral auditory evoked responses was evaluated by comparing the P1 evoked responses to the first and second of paired auditory stimuli. Cerebral evoked responses were recorded during active sleep from 22 infants with a parent diagnosed with a psychotic illness and 129 infants with parents with no such history. Of these infants, 25 were prenatally exposed to nicotine (16 from the comparison group and 9 from the group with parental psychosis). Mothers of 35 infants had diagnoses of major depressive disorder. Parental psychosis (P = .032) and exposure to maternal smoking (P = .012) both resulted in diminished inhibitory gating in infant offspring. Compared to infants of mothers who did not smoke and who had neither parental psychosis nor maternal depression, diminished inhibitory gating was observed in infants with parental psychosis (P = .027) and in infants with maternal depression (P = .049). Diminished inhibitory gating of auditory evoked response in infants who have risk factors for schizophrenia mirrors reports of its familial transmission in adults. The results further indicate that the phenotypic expression of familial genetic and environmental risks for psychosis is already manifest very early in development.Keywords
This publication has 46 references indexed in Scilit:
- Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: Results from the Consortium on Genetics of SchizophreniaSchizophrenia Research, 2010
- Research Review: Cholinergic mechanisms, early brain development, and risk for schizophreniaJournal of Child Psychology and Psychiatry, 2010
- Large recurrent microdeletions associated with schizophreniaNature, 2008
- Sensory Gating Endophenotype Based on Its Neural Oscillatory Pattern and Heritability EstimateArchives of General Psychiatry, 2008
- Altered hippocampal circuit function in C3H α7 null mutant heterozygous miceBrain Research, 2008
- Increased hemodynamic response in the hippocampus, thalamus and prefrontal cortex during abnormal sensory gating in schizophreniaSchizophrenia Research, 2007
- The Genetic Deconstruction of PsychosisSchizophrenia Bulletin, 2007
- Associations of Maternal Prenatal Smoking with Early Childhood Physical Aggression, Hyperactivity-Impulsivity, and Their Co-OccurrenceJournal of Abnormal Child Psychology, 2007
- Deconstructing Schizophrenia: An Overview of the Use of Endophenotypes in Order to Understand a Complex DisorderSchizophrenia Bulletin, 2006
- The α7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophreniaJournal of Chemical Neuroanatomy, 2000