Ferromagnetic embolization. Experimental evaluation.

Abstract

Flow of embolized carbonyl Fe particles under the influence of a magnetic field was evaluated in vitro and in vivo. The magnetic force caused particles to form aggregates, obstructing tubing or vascular beds. In dogs, 0.5 cm3 of Fe particles injected into a renal artery under magnetic control caused total occlusion and necrosis. Injection without magnetic control caused little damage and no change in function. There was little systemic toxicity. Injection of Fe particles under magnetic control may be helpful in embolic arterial occlusion and localized irradiation, hyperthermia and chemotherapy.