A dual cytotoxic and anti-angiogenic water-soluble gold(iii) complex induces endoplasmic reticulum damage in HeLa cells
- 1 January 2012
- journal article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 48 (28), 3388-3390
- https://doi.org/10.1039/c2cc00029f
Abstract
The water-soluble gold(III) complex [AuIII(butyl-CN)biguanide]Cl (butyl-HCN = 2-(4-n-butylphenyl)pyridine, BCN) displays cytotoxicity through S-phase cell cycle arrest and endoplasmic reticulum (ER) damage in HeLa cells, and shows a promising anti-angiogenic effect at sub-cytotoxic concentrations.Keywords
This publication has 25 references indexed in Scilit:
- Therapeutic applications of gold complexes: lipophilic gold(iii) cations and gold(i) complexes for anti-cancer treatmentChemical Communications, 2011
- Cyclometalated gold(iii) complexes with N-heterocyclic carbene ligands as topoisomerase I poisonsChemical Communications, 2010
- A Gold(III) Porphyrin Complex with Antitumor Properties Targets the Wnt/β-catenin PathwayCancer Research, 2010
- Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold(III) compounds for cancer treatment: a systematic studyJBIC Journal of Biological Inorganic Chemistry, 2009
- A gold(I) phosphine complex selectively induces apoptosis in breast cancer cells: Implications for anticancer therapeutics targeted to mitochondriaBiochemical Pharmacology, 2007
- Anticancer Cyclometalated [AuIIIm(C∧N∧C)mL]n+ Compounds: Synthesis and Cytotoxic PropertiesChemistry – A European Journal, 2006
- Mechanisms of Cytotoxicity of Selected Organogold(III) CompoundsJournal of Medicinal Chemistry, 2005
- Gold(III) Complexes with Bipyridyl Ligands: Solution Chemistry, Cytotoxicity, and DNA Binding PropertiesJournal of Medicinal Chemistry, 2002
- Gold(III) Complexes as Potential Antitumor Agents: Solution Chemistry and Cytotoxic Properties of Some Selected Gold(III) CompoundsJournal of Medicinal Chemistry, 2000
- Novel luminescent cyclometaiated and terpyridine gold(III) complexes and DNA binding studiesJournal of the Chemical Society, Chemical Communications, 1995