Effects of Reconstituted High-Density Lipoprotein Infusions on Coronary AtherosclerosisA Randomized Controlled Trial

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Abstract
Despite highly effective contemporary treatment regimens, the majority of vascular events are not prevented, particularly in high-risk individuals.1,2 Therefore, further strategies to decrease atherosclerosis burden and improve cardiovascular outcomes are needed. There is a strong inverse association between high-density lipoprotein (HDL) cholesterol and risk of coronary heart disease in epidemiological studies.3,4