Human Papillomavirus in Clinically and Histologically Normal Tissue of Patients with Genital Cancer
- 23 October 1986
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 315 (17), 1052-1058
- https://doi.org/10.1056/nejm198610233151703
Abstract
To study the association of human papillomavirus (HPV) and herpes simplex virus (HSV) with genital cancer, we collected specimens of cervical, vulvar, endometrial, and vaginal tumors at the time of operation in patients with cancer. In some patients, matched internalcontrol (histologically normal) tissue was also collected. DNA extracted from the tissue was probed with Radio-labeled HPV type 16 DNA, HPV type 18 DNA, and cloned fragments of HSV type 2 DNA.Keywords
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