The Influence of Hypertonic Saline Infusions Upon the Fractional Reabsorption of Urate and Other Ions in Normal and Hypertensive Man
- 1 January 1970
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 41 (1), 97-108
- https://doi.org/10.1161/01.cir.41.1.97
Abstract
Renal hemodynamics and the excretion rates of six ions were studied in a group of 24 normotensive and hypertensive subjects during expansion of extracellular fluid volume (ECF) with intravenous infusions of hypertonic saline. In response to the 2.5% saline infusions arterial blood pressure did not change from control values, but glomerular filtration rate increased, and renal vascular resistance decreased. Accompanying these hemodynamic alterations the urinary excretion rates of sodium, calcium, magnesium, potassium, chloride, and urate increased significantly. Net fractional reabsorption of the six ions fell significantly below control values. The induced changes in net Ca, Mg, K, Cl, and urate reabsorption in all the subjects were directly and significantly related to the simultaneous depression of Na reabsorption. The data indicate that increased excretion and net tubular rejection of urate accompany depression of tubular sodium reabsorption during hypertonic saline infusions in normal and hypertensive man. The nonspecificity of depressed fractional ion reabsorption during the infusions is compatible with the hypothesis that physical forces which alter fluid uptake by peritubular capillaries determine to a significant extent the natriuretic response of the human nephron to hypertonic saline infusions. Alternatively, if a natriuretic hormone elicited by ECF volume expansion in man accounts for the depressed fractional Na reabsorption, the data imply that directly or indirectly this substance inhibits net fractional reabsorption of a variety of other ions.Keywords
This publication has 31 references indexed in Scilit:
- Effect of acute hypertension on sodium reabsorption by the proximal tubuleJCI Insight, 1968
- Depression of fractional sodium reabsorption by the proximal tubule of the dog without sodium diuresisJCI Insight, 1968
- Functional Characteristics of the Diluting Segment of the Dog Nephron and the Effect of Extracellular Volume Expansion on its Reabsorptive Capacity*JCI Insight, 1967
- The Effects of Infusion of Water on Renal Hemodynamics and the Tubular Reabsorption of Sodium*JCI Insight, 1967
- Mathematical aspects of renal function: The dependence of solute reabsorption on water reabsorption, and the mechanism of osmotic natriuresisJournal of Theoretical Biology, 1966
- The Effect of Saline Infusion on Sodium Reabsorption by the Proximal Tubule of the Dog*JCI Insight, 1965
- THE MECHANISM OF SODIUM DIURESIS AFTER SALINE INFUSION IN THE DOG*JCI Insight, 1963
- ION ASSOCIATION. VI. INTERACTIONS BETWEEN CALCIUM, MAGNESIUM, INORGANIC PHOSPHATE, CITRATE AND PROTEIN IN NORMAL HUMAN PLASMA*JCI Insight, 1961
- THE RENAL RESPONSE TO INTRAVENOUS INJECTION OF SODIUM CHLORIDE SOLUTIONS IN MAN 1JCI Insight, 1951
- An Enzymatic Method for the Determination of Uric Acid by Ultraviolet SpectrofhotometryScandinavian Journal of Clinical and Laboratory Investigation, 1949