Studies of the Mortality of Atomic Bomb Survivors, Report 14, 1950–2003: An Overview of Cancer and Noncancer Diseases
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Open Access
- 1 March 2012
- journal article
- Published by Radiation Research Society in Radiation Research
- Vol. 177 (3), 229-243
- https://doi.org/10.1667/rr2629.1
Abstract
This is the 14th report in a series of periodic general reports on mortality in the Life Span Study (LSS) cohort of atomic bomb survivors followed by the Radiation Effects Research Foundation to investigate the late health effects of the radiation from the atomic bombs. During the period 1950–2003, 58% of the 86,611 LSS cohort members with DS02 dose estimates have died. The 6 years of additional follow-up since the previous report provide substantially more information at longer periods after radiation exposure (17% more cancer deaths), especially among those under age 10 at exposure (58% more deaths). Poisson regression methods were used to investigate the magnitude of the radiation-associated risks, the shape of the dose response, and effect modification by gender, age at exposure, and attained age. The risk of all causes of death was positively associated with radiation dose. Importantly, for solid cancers the additive radiation risk (i.e., excess cancer cases per 104 person-years per Gy) continues to increase throughout life with a linear dose–response relationship. The sex-averaged excess relative risk per Gy was 0.42 [95% confidence interval (CI): 0.32, 0.53] for all solid cancer at age 70 years after exposure at age 30 based on a linear model. The risk increased by about 29% per decade decrease in age at exposure (95% CI: 17%, 41%). The estimated lowest dose range with a significant ERR for all solid cancer was 0 to 0.20 Gy, and a formal dose-threshold analysis indicated no threshold; i.e., zero dose was the best estimate of the threshold. The risk of cancer mortality increased significantly for most major sites, including stomach, lung, liver, colon, breast, gallbladder, esophagus, bladder and ovary, whereas rectum, pancreas, uterus, prostate and kidney parenchyma did not have significantly increased risks. An increased risk of non-neoplastic diseases including the circulatory, respiratory and digestive systems was observed, but whether these are causal relationships requires further investigation. There was no evidence of a radiation effect for infectious or external causes of death.Keywords
This publication has 19 references indexed in Scilit:
- Ionizing Radiation and Leukemia Mortality among Japanese Atomic Bomb Survivors, 1950–2000Radiation Research, 2009
- Is cancer risk of radiation workers larger than expected?Occupational and Environmental Medicine, 2009
- Heterogeneity of variation of relative risk by age at exposure in the Japanese atomic bomb survivorsRadiation and Environmental Biophysics, 2009
- Heterogeneity of variation of relative risk by age at exposure in the Japanese atomic bomb survivorsRadiation and Environmental Biophysics, 2009
- Solid Cancer Incidence in Atomic Bomb Survivors: 1958–1998Radiation Research, 2007
- Dose Estimation for Atomic Bomb Survivor Studies: Its Evolution and Present StatusRadiation Research, 2006
- Effect of Recent Changes in Atomic Bomb Survivor Dosimetry on Cancer Mortality Risk EstimatesRadiation Research, 2004
- Studies of Mortality of Atomic Bomb Survivors. Report 13: Solid Cancer and Noncancer Disease Mortality: 1950–1997Radiation Research, 2003
- Studies of the mortality of atomic bomb survivors. Report 12, part II. Noncancer mortality: 1950-1990.Radiation Research, 1999
- A new look at the statistical model identificationIEEE Transactions on Automatic Control, 1974