Reversible Renal Failure and Nephrotic Syndrome Associated with Nonsteroidal Anti-Inflammatory Drugs

Abstract

REVERSIBLE renal failure and nephrotic syndrome developed in three patients taking therapeutic doses of either fenoprofen or naproxen; both drugs are phenylalkanoic acids used as anti-inflammatory agents. We present here the clinical and pathological features of this complication.Case ReportsA 51-year-old woman (Patient 1) was admitted to the hospital on May 7, 1977, because of nausea, dizziness, and swelling of her legs for several days. She had a five-year history of rheumatoid arthritis. Since August, 1976, she had been taking fenoprofen, 1800 mg to 2400 mg daily, and prednisone, 5 mg daily. Gold therapy preceded the use of fenoprofen, . . .