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Data from Validation of Genome-Wide Prostate Cancer Associations in Men of African Descent
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Data from Validation of Genome-Wide Prostate Cancer Associations in Men of African Descent
Data from Validation of Genome-Wide Prostate Cancer Associations in Men of African Descent
BC
Bao-Li Chang
Bao-Li Chang
ES
Elaine Spangler
Elaine Spangler
SG
Stephen Gallagher
Stephen Gallagher
CH
Christopher A. Haiman
Christopher A. Haiman
BH
Brian Henderson
Brian Henderson
WI
William Isaacs
William Isaacs
MB
Marnita L. Benford
Marnita L. Benford
LK
LaCreis R. Kidd
LaCreis R. Kidd
KC
Kathleen Cooney
Kathleen Cooney
SS
Sara Strom
Sara Strom
SI
Sue Ann Ingles
Sue Ann Ingles
MS
Mariana C. Stern
Mariana C. Stern
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31 March 2023
other
Published by
American Association for Cancer Research (AACR)
https://doi.org/10.1158/1055-9965.c.6514782.v1
Abstract
Background: Genome-wide association studies (GWAS) have identified numerous prostate cancer susceptibility alleles, but these loci have been identified primarily in men of European descent. There is limited information about the role of these loci in men of African descent.Methods: We identified 7,788 prostate cancer cases and controls with genotype data for 47 GWAS-identified loci.Results: We identified significant associations for SNP rs10486567 at JAZF1, rs10993994 at MSMB, rs12418451 and rs7931342 at 11q13, and rs5945572 and rs5945619 at NUDT10/11. These associations were in the same direction and of similar magnitude as those reported in men of European descent. Significance was attained at all reported prostate cancer susceptibility regions at chromosome 8q24, including associations reaching genome-wide significance in region 2.Conclusion: We have validated in men of African descent the associations at some, but not all, prostate cancer susceptibility loci originally identified in European descent populations. This may be due to the heterogeneity in genetic etiology or in the pattern of genetic variation across populations.Impact: The genetic etiology of prostate cancer in men of African descent differs from that of men of European descent. Cancer Epidemiol Biomarkers Prev; 20(1); 23–32. ©2011 AACR.
Keywords
PROSTATE CANCER
MEN OF AFRICAN
ETIOLOGY
AFRICAN DESCENT
GWAS
LOCI
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