Prevalence of hyperuricemia and its related risk factors in healthy adults from Northern and Northeastern Chinese provinces
Open Access
- 17 July 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Public Health
- Vol. 13 (1), 664-9
- https://doi.org/10.1186/1471-2458-13-664
Abstract
Background Hyperuricemia (HUA) is a potential risk factor for developing insulin resistance, hypertension, dyslipidemia and cardiovascular disease. Therefore, we studied the prevalence of HUA and associated risk factors in the population of two provinces in northern China. Methods Based on the research of Chinese Physiological Constant and Health Conditions conducted in 2008–2010, we enrolled 29,639 subjects in a randomized, stratified study in four sampling areas in Heilongjiang Province and the Inner Mongolia Autonomous Region. We collected 13,140 serum samples to determine biochemical indicators including uric acid(UA), glucose, blood lipids, liver function, and renal function, and finally a representative sample of 8439 aged 18 years and older was determined. We also defined and stratified HUA, hypertension, diabetes, obesity and lipid abnormalities according to international guidelines. Results There were significant differences in the UA levels between different genders and regions. The total prevalence of HUA is 13.7%. Men had a higher prevalence of HUA than women (21% vs. 7.9%; P < 0.0001). As age increased, HUA prevalence decreased in men but rose in women. The suburbs of big cities had the highest HUA prevalence (18.7%), and in high-prevalence areas the proportion of women with HUA also increased. A stepwise logistic regression model was used to filter out twelve HUA risk factors, including age, gender, residence, hypercholesterolemia, hypertriglyceridemia, impaired fasting glucose, hypertension, obesity, abdominal obesity, CKD, drinking and sleeping. After adjusting for these factors, the odds ratio of HUA was 1.92 times higher in men than in women. Compared with agricultural and pastoral areas, the odds ratio of having HUA was 2.14 for participants in the suburbs of big cities and 1.57 in the center of big cities. Conclusions The prevalence of HUA is high in northern China. The differences in HUA prevalence by geographic region suggested that unbalanced economic development and health education, therefore HUA prevention measures should be strengthened to improve quality of life and reduce health care costs.This publication has 22 references indexed in Scilit:
- The prevalence of hyperuricemia in China: a meta-analysisBMC Public Health, 2011
- Prevalence of hyperuricemia in Bangkok populationClinical Rheumatology, 2011
- Metabolic Syndrome Characteristics in Gout PatientsNucleosides, Nucleotides and Nucleic Acids, 2010
- The role of hyperuricemia in vascular disordersCurrent Opinion in Rheumatology, 2009
- Uric acid: A marker of increased cardiovascular riskAtherosclerosis, 2009
- Hyperuricemia, gout and the metabolic syndromeCurrent Opinion in Rheumatology, 2008
- Prevalence of the Metabolic Syndrome in Individuals with HyperuricemiaAmerican Journal Of Medicine, 2007
- Prevalence of Hyperuricemia and its Relationship with Metabolic Syndrome in Thai Adults Receiving Annual Health ExamsArchives of Medical Research, 2006
- Low serum testosterone level as a predictor of increased visceral fat in Japanese-American menInternational Journal of Obesity, 2000
- Hyperuricemia and insulin resistanceJournal of Clinical Endocrinology & Metabolism, 1994