Wiring optimization can relate neuronal structure and function
- 14 March 2006
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 103 (12), 4723-4728
- https://doi.org/10.1073/pnas.0506806103
Abstract
We pursue the hypothesis that neuronal placement in animals minimizes wiring costs for given functional constraints, as specified by synaptic connectivity. Using a newly compiled version of the Caenorhabditis elegans wiring diagram, we solve for the optimal layout of 279 nonpharyngeal neurons. In the optimal layout, most neurons are located close to their actual positions, suggesting that wiring minimization is an important factor. Yet some neurons exhibit strong deviations from "optimal" position. We propose that biological factors relating to axonal guidance and command neuron functions contribute to these deviations. We capture these factors by proposing a modified wiring cost function.Keywords
This publication has 50 references indexed in Scilit:
- Segregation of the Brain into Gray and White Matter: A Design Minimizing Conduction DelaysPLoS Computational Biology, 2005
- Genetic analysis of synaptic target recognition and assemblyTrends in Neurosciences, 2004
- Biophysical constraints on neuronal branchingNeurocomputing, 2004
- The Immunoglobulin Superfamily Protein SYG-1 Determines the Location of Specific Synapses in C. elegansCell, 2003
- Molecular Mechanisms of Axon GuidanceScience, 2002
- Immunoglobulin-Domain Proteins Required for Maintenance of Ventral Nerve Cord OrganizationScience, 2002
- CorrespondenceTrends in Neurosciences, 1996
- The GABAergic nervous system of Caenorhabditis elegansNature, 1993
- The structure of the nervous system of the nematodeCaenorhabditis elegansPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1986
- Post-embryonic cell lineages of the nematode, Caenorhabditis elegansDevelopmental Biology, 1977